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Urinary system disease model


Aniphe BioLab develops urinary system disease models based on key pathological mechanisms, including impaired renal filtration, urinary tract inflammation, and metabolic injury. These models support in vivo research on nephritis, renal fibrosis, urinary tract infections, and metabolic kidney injury.
By reproducing renal inflammation, glomerular injury, and changes in the urinary tract microenvironment, our models provide reliable platforms for disease mechanism studies and drug evaluation. Applications include renoprotective, anti-inflammatory, and antifibrotic therapies, as well as research on renal dysfunction and urinary tract infections.

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Mechanism-oriented
Precision Modeling
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Multiple reviews
System Verification
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Phenotypic stability
Repeatability
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University Support
Accelerate R&D
Urinary system disease model

Characteristics of the Aniphe BioLab Urinary System Disease Model

In response to the research needs surrounding renal injury and urinary system dysfunction, Aniphe BioLab has established a standardized animal model system for urological diseases, ensuring model stability and experimental reproducibility.

 

 Comprehensive model coverage

Comprehensive coverage of model types
It encompasses common disease models, including nephritis, renal fibrosis, acute and chronic kidney injury, and urinary tract infections, thereby meeting multi-level research needs.

 Standardization of the modeling process

Standardization of the modeling process
Standardize the modeling method, induction dose, and time window to minimize the impact of individual variability on experimental outcomes.

 Multidimensional Evaluation System

Multidimensional Evaluation System
By integrating renal function parameters, histopathological findings, and inflammatory cytokine assays, a comprehensive assessment of structural damage and functional alterations can be achieved.

 Standardization of Data Delivery

Standardization of Data Delivery
Provide raw experimental data, pathological images, and analytical results to ensure data traceability and compliance with publication and regulatory submission requirements.

 

Animal models of urological diseases, by mimicking renal injury and functional abnormalities, provide a stable and reproducible in vivo experimental platform for studying disease mechanisms and developing therapeutic agents.
 

Product List:


Disease Name

Disease model

Details

 Comprehensive model coverage Glioblastoma

U87-MG-luc orthotopic animal model

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 Comprehensive model coverage Alzheimer's disease

Alzheimer’s disease AD animal model

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 Comprehensive model coverage Encephalomyelitis

Allergic encephalomyelitis animal model of AE

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 Comprehensive model coverage Post-traumatic stress disorder

Animal model of post-traumatic stress disorder (PTSD)

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 Comprehensive model coverage Traumatic brain injury

Animal model of traumatic brain injury

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 Comprehensive model coverage Epilepsy

Epilepsy animal model

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 Comprehensive model coverage Spinal cord injury

Animal model of spinal cord injury

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 Comprehensive model coverage Anxiety disorder

Anxiety disorder animal model

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 Comprehensive model coverage Neurological dysfunction after TBI

Animal model of electrical stimulation for traumatic brain injury

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 Comprehensive model coverage Traumatic brain injury

Animal model of traumatic brain injury

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 Comprehensive model coverage Depression

Chronic Unpredictable Mild Stress (CUMS) animal model

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 Comprehensive model coverage Hemorrhagic stroke

Animal model of cerebral hemorrhage

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Cerebral ischemia MCAO animal model

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 Comprehensive model coverage Sepsis-associated encephalopathy

Sepsis-induced brain injury model

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 Comprehensive model coverage Parkinson's disease

Parkinson’s disease animal model

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 Comprehensive model coverage Hepatic encephalopathy (early stage)

Mild hepatic encephalopathy model

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 Comprehensive model coverage Hypoxic-ischemic brain injury

Hypoxic-ischemic encephalopathy (HIE) animal model

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 Comprehensive model coverage Trigeminal neuralgia

Trigeminal neuralgia animal model

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 Comprehensive model coverage Sleep disorder

Animal models of sleep disorders/insomnia

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 Comprehensive model coverage Vascular dementia

Vascular dementia animal model

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 Comprehensive model coverage Depression

Animal model of depression

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 Comprehensive model coverage Multiple sclerosis

Animal model of autoimmune encephalomyelitis

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 Comprehensive model coverage Neuropathic pain

Sciatic nerve compression animal model

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Disease Name

Disease model

Construction method

 Comprehensive model coverage Migraine

Migraine model

Nitroglycerin injection, dural inflammation-induced stimulation (application of inflammatory substances)

 Comprehensive model coverage Hypopituitarism

Pituitaryectomy model

Surgical removal of the pituitary gland (via the transsphenoidal or transcranial approach)

 Comprehensive model coverage Suppurative osteomyelitis

Experimental model of osteomyelitis

Tibial drilling and injection of Staphylococcus aureus

 Comprehensive model coverage Ischemic tolerance induction

Hypoxic preconditioning model

Severe ischemia induced after repeated brief hypoxic exposures (in normobaric or hypobaric chambers)

 Comprehensive model coverage Vestibular dysfunction

Unilateral labyrinthectomy model

Surgical destruction of the unilateral vestibular organ in rats and guinea pigs.

 Comprehensive model coverage Antipsychotic-induced bone loss

Schizophrenia-induced osteoporosis model

Long-term administration of antipsychotic agents (such as haloperidol) in combination with ovariectomy or glucocorticoid induction

 Comprehensive model coverage Periprosthetic osteolysis

Cranial bone dissolution model

Cranial implantation of titanium particles or inflammatory factors (TNF-α/polyethylene particles)

 Comprehensive model coverage Post-ischemic epilepsy

Global cerebral ischemic epilepsy model

Seizures following bilateral common carotid artery ligation combined with hypotension-induced ischemia

Disease Name

Disease model

Details

Animal model of acute kidney injury (AKI)

Chronic renal failure (CRF) animal model

Urinary stone animal model

Prostate cancer CDX animal model

Renal ischemia-reperfusion injury (RIRI) animal model

Animal models of glomerular diseases

Diabetic kidney disease (DKD) animal model

Stress urinary incontinence (SUI) animal model

Disease Name

Disease model

Construction method

Acute tubular necrosis

Renal ischemia-reperfusion model

Clamp both renal pedicles, release the vascular clamps to restore blood flow and reperfusion.

Bladder Obstructive Disease

Bladder outlet obstruction model

Surgical ligation of the urethra

Bacterial pyelonephritis

Acute pyelonephritis model

Temporary ligation of the ureter plus intravesical instillation of Escherichia coli