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Imaging-based behavioral analysis of small animals

Aniphe BioLab offers an integrated experimental service platform encompassing “animal behavioral assessment + small-animal imaging,” catering to research needs across multiple fields—including neuroscience, metabolic diseases, oncology, and drug efficacy evaluation—and establishing a comprehensive evidence chain that spans from behavioral phenotyping to in vivo structural and functional imaging.

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Animal Behavior

Aniphe BioLab has established a standardized, systematic in vivo experimental research platform in the fields of animal behavior and imaging. Equipped with well‑organized animal‑experiment facilities and specialized behavioral assessment equipment, the platform enables comprehensive multidimensional behavioral evaluations, including learning and memory, anxiety and depression, addictive behaviors, pain perception, neuropsychiatric functions, and exercise‑induced fatigue. It covers classic experimental paradigms such as the Morris water maze, Y‑maze, novel object recognition, elevated plus maze, open field test, spontaneous activity assays, and treadmill running tests. The platform integrates behavior‑observation and data‑analysis systems, allowing simultaneous acquisition and quantitative analysis of multiple behavioral parameters. This approach provides a more holistic and objective characterization of experimental animal behavior, significantly enhancing data reproducibility and inter‑study consistency. Furthermore, the platform has developed a standardized neurobehavioral experimental workflow that complies with international guidelines, offering robust methodological support for mechanistic studies and drug‑efficacy assessments.

Comprehensive model coverage

Standardization

Standardized behavioral experimental procedures ensure result consistency.

Standardization of the modeling process

Multidimensional Assessment

Covers multidimensional behavioral models encompassing cognition, emotion, motor function, and more.

Multidimensional Evaluation System

Data is reliable.

Automated data collection and analysis enhance data reproducibility.

Adapted for multi-cycle studies

Compliance Assurance

Complies with international standards for the ethics and quality of laboratory animals.

Standardization of Data Delivery

Integrated platform

Behavioral and imaging assessments are combined to establish a comprehensive chain of evidence.

Experiment Name	Content	Explanation
Learning and Memory Behavioral Science	Morris Water Maze (5 training trials, 1 test trial)	Adaptation for 3 days, training for 5 days, testing for 1 day, and data analysis for 1 day.
	Dark avoidance test	One day for adapting to the environment, one day for testing, and one day for data analysis.
	Y-maze experiment	One day for adapting to the environment, one day for testing, and one day for data analysis.
	New Object Recognition Experiment
	Three boxes of experiments
	Shuttle experiment	One day for adapting to the environment, one day for testing, and one day for data analysis.
	Conditioned Fear Experiment
Anxiety and Depression Behavioral Science	Elevated Cross Maze	One day for adapting to the environment, one day for testing, and one day for data analysis.
	Tail suspension test	One day for adapting to the environment, one day for testing, and one day for data analysis.
	Black-and-white box/dark-and-light box experiment	One day for adapting to the environment, one day for testing, and one day for data analysis.
	Bead-embedding experiment
	Preference for sweet drinks	Adapt to drinking water for one day, followed by one day of sugar water mixed with water, then one day of water deprivation, and finally one day of testing.
Behavioral Pharmacology of Addiction	Climbing-wall behavior experiment	One day for adapting to the environment, one day for testing, and one day for data analysis.
Pain behaviorology	Von Frey nociceptive test	One day for adapting to the environment, one day for testing, and one day for data analysis.
Pain behaviorology	Cold–hot plate test for pain measurement	One day for adapting to the environment, one day for testing, and one day for data analysis.
Neuropsychiatric Abnormal Behavior Studies	Open-field test	One day for adapting to the environment, one day for testing, and one day for data analysis.
Fatigue Behaviorology	Rotarod test	One day for adapting to the environment, one day for testing, and one day for data analysis.
	Forced swimming test	One day for adapting to the environment, one day for testing, and one day for data analysis.
	Gait detection	One day adapting to the environment, one day testing, and one day analyzing data (without analysis).
	Treadmill test	One day for adapting to the environment, one day for testing, and one day for data analysis.
Other behavioral aspects	Grid misalignment
	Sticker removal
	Drill pipe testing

Small Animal Imaging

In the realm of animal imaging, the platform integrates a suite of advanced multimodal imaging technologies, including B‑ultrasound, X‑ray, in vivo IVIS imaging, photoacoustic/photothermal imaging, 9.4T MRI, PET/CT, and micro‑CT. This comprehensive infrastructure enables noninvasive, dynamic, multiscale tracking and analysis across scales—from molecular signals to tissue architecture—providing high‑resolution imaging evidence to support disease‑model validation, drug‑distribution assessment, and mechanistic elucidation.

Experiment Name	Explanation
Ultrasound	Except for lung imaging.
X-ray inspection	Ex vivo / in vivo
In Vivo Imaging IVIS	Contains anesthetic fluorescent reagent
Photoacoustic imaging	The activation fee is billed separately and requires an assessment.
Photothermal imaging	The activation fee is billed separately and requires an assessment.
Nuclear magnetic resonance	Startup fee is billed separately: 9T
PET/CT scan	The activation fee is billed separately and includes FDG.
Micro-CT (medium resolution)	Startup fees are billed separately, ex vivo/vivo.
In Vivo Body Fat Analysis in Small Animals	The activation fee is billed separately and requires an assessment.
Laser Speckle Blood Flow Imaging	The activation fee is billed separately and requires an assessment.
Colonoscopy	See the specific plan.
Metabolic cage (respiratory quotient)	Adaptive feeding + 24-hour data volume