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Endocrine and Immune system models


Aniphe BioLab develops endocrine disease models based on key pathological mechanisms, including hormonal imbalance and metabolic dysregulation. These models support research on diabetes, obesity, thyroid disorders, and metabolic syndrome.
By reproducing insulin resistance, glucose and lipid metabolism disorders, and endocrine axis dysfunction, our models provide reliable in vivo platforms for disease mechanism studies and drug screening. Applications include glucose-lowering and metabolic therapies, endocrine target research, and studies of obesity, diabetic complications, and metabolic inflammation.

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Mechanism-oriented
Precision Modeling
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Multiple reviews
System Verification
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Phenotypic stability
Repeatability
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University Support
Accelerate R&D
Endocrine and Immune system models

Characteristics of the Aniphe BioLab Endocrine System Disease Model


In response to research needs related to metabolic homeostasis disruption and hormonal dysregulation, Aniphe BioLab has established a standardized animal model platform for endocrine system disorders, ensuring model stability and data consistency.

 Comprehensive model coverage

Comprehensive coverage of model types
It encompasses common models of diabetes, obesity, thyroid dysfunction, and metabolic syndrome, meeting the needs of metabolic and endocrine research.

 Standardization of the modeling process

Standardization of the modeling process
Dietary induction, pharmacological modeling, and experimental timelines were uniformly controlled to minimize the impact of environmental and procedural variability on metabolic phenotypes.

 Multidimensional Evaluation System

Multidimensional evaluation system
By integrating glycemic and lipid profiles, insulin sensitivity, and histopathological analyses, a comprehensive assessment of metabolic function and organ damage can be achieved.

 Standardization of Data Delivery

Standardization of Data Delivery
Provide raw experimental data, metabolic markers, and imaging results to ensure data traceability and compliance with publication and regulatory submission requirements.
 

 

Animal models of endocrine system disorders, by mimicking the dysregulation of metabolic and hormonal homeostasis, provide a stable and reproducible in vivo experimental platform for investigating the pathogenesis of metabolic diseases and for drug development.
 

Product List:


Disease Name

Disease model

Details

 Comprehensive model coverage Glioblastoma

U87-MG-luc orthotopic animal model

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 Comprehensive model coverage Alzheimer's disease

Alzheimer’s disease AD animal model

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 Comprehensive model coverage Encephalomyelitis

Allergic encephalomyelitis animal model of AE

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 Comprehensive model coverage Post-traumatic stress disorder

Animal model of post-traumatic stress disorder (PTSD)

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 Comprehensive model coverage Traumatic brain injury

Animal model of traumatic brain injury

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 Comprehensive model coverage Epilepsy

Epilepsy animal model

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 Comprehensive model coverage Spinal cord injury

Animal model of spinal cord injury

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 Comprehensive model coverage Anxiety disorder

Anxiety disorder animal model

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 Comprehensive model coverage Neurological dysfunction after TBI

Animal model of electrical stimulation for traumatic brain injury

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 Comprehensive model coverage Traumatic brain injury

Animal model of traumatic brain injury

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 Comprehensive model coverage Depression

Chronic Unpredictable Mild Stress (CUMS) animal model

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 Comprehensive model coverage Hemorrhagic stroke

Animal model of cerebral hemorrhage

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Cerebral ischemia MCAO animal model

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 Comprehensive model coverage Sepsis-associated encephalopathy

Sepsis-induced brain injury model

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 Comprehensive model coverage Parkinson's disease

Parkinson’s disease (PD) animal model

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 Comprehensive model coverage Hepatic encephalopathy (early stage)

Mild hepatic encephalopathy model

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 Comprehensive model coverage Hypoxic-ischemic brain injury

Hypoxic-ischemic encephalopathy (HIE) animal model

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 Comprehensive model coverage Trigeminal neuralgia

Trigeminal neuralgia animal model

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 Comprehensive model coverage Sleep disorder

Animal models of sleep disorders/insomnia

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 Comprehensive model coverage Vascular dementia

Vascular dementia animal model

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 Comprehensive model coverage Depression

Animal model of depression

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 Comprehensive model coverage Multiple sclerosis

Animal model of autoimmune encephalomyelitis

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 Comprehensive model coverage Neuropathic pain

Sciatic nerve compression animal model

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Disease Name

Disease model

Construction method

 Comprehensive model coverage Migraine

Migraine model

Nitroglycerin injection, dural inflammation-induced stimulation (application of inflammatory substances)

 Comprehensive model coverage Hypopituitarism

Pituitaryectomy model

Surgical removal of the pituitary gland (via the transsphenoidal or transcranial approach)

 Comprehensive model coverage Suppurative osteomyelitis

Experimental model of osteomyelitis

Tibial drilling and injection of Staphylococcus aureus

 Comprehensive model coverage Ischemic tolerance induction

Hypoxic preconditioning model

Severe ischemia is induced following repeated short-term hypoxic exposures (in normobaric or hypobaric chambers).

 Comprehensive model coverage Vestibular dysfunction

Unilateral labyrinthectomy model

Surgical destruction of the unilateral vestibular apparatus in rats and guinea pigs.

 Comprehensive model coverage Antipsychotic-induced bone loss

Schizophrenia-induced osteoporosis model

Long-term administration of antipsychotic agents (such as haloperidol) in combination with ovariectomy or glucocorticoid induction

 Comprehensive model coverage Periprosthetic osteolysis

Cranial bone dissolution model

Cranial implantation of titanium particles or inflammatory factors (TNF-α/polyethylene particles)

 Comprehensive model coverage Post-ischemic epilepsy

Global cerebral ischemic epilepsy model

Seizures following bilateral common carotid artery ligation and hypotension-induced ischemia

Disease Name

Disease model

Details

Type 1 diabetes T1DM animal model

Type 2 Diabetes Mellitus (T2DM) Animal Model

Allergic Rhinitis AR Animal Model

Animal model of hyperuricemia

Rheumatoid arthritis (RA) animal model

Disease Name

Disease model

Construction method

Hashimoto's thyroiditis

Autoimmune thyroiditis model

Iodine excess

Diabetic foot ulcer

Diabetic foot disease model

STZ-induced diabetes with full-thickness skin excision of the plantar surface

Diabetic chronic wounds

Diabetic wound model

STZ-induced diabetes with a dorsal wound