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Reproductive system disease model


Aniphe BioLab develops reproductive disease models based on key pathological mechanisms, including hormonal imbalance, abnormal inflammatory responses, tissue remodeling, and local microenvironment dysregulation. These models support in vivo research on endometriosis and ovarian dysfunction.
By reproducing disrupted hormonal cycles, sustained inflammatory cytokine release, and reproductive tissue fibrosis and adhesion formation, our models provide reliable platforms for disease mechanism studies and drug evaluation. Applications include anti-inflammatory and hormonal therapies, reproductive tissue repair, and research on reproductive endocrine regulation and tissue remodeling.

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Mechanism-oriented
Precision Modeling
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Multiple reviews
System Verification
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Phenotypic stability
Repeatability
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University Support
Accelerate R&D
Reproductive system disease model

Characteristics of the Aniphe BioLab Reproductive System Disease Model

In response to the research needs surrounding dysregulation of the reproductive system’s microenvironmental homeostasis and associated histopathological changes, Ailinfei Biotechnology has established a standardized animal model platform for reproductive system diseases, characterized by the following key features:
 

 Comprehensive model coverage

  Comprehensive coverage of model types
It encompasses common disease models such as endometriosis, pelvic inflammatory disease, ovarian dysfunction, and tubal damage, thereby meeting the needs of basic research on reproductive disorders and drug‑efficacy evaluation.

 Standardization of the modeling process

Standardization of the modeling process
Standardize and rigorously control hormone‑induced protocols, local inflammatory stimuli, and tissue transplantation/injury procedures to minimize the impact of individual variability on experimental outcomes.

 Multidimensional Evaluation System

  Multidimensional Evaluation System
By integrating histopathological analysis, hormonal profiling, inflammatory cytokine assessment, and evaluation of reproductive function parameters, a comprehensive determination of both structural and functional status can be achieved.

 Standardization of Data Delivery

Standardization of Data Delivery
Provide raw experimental data, imaging results, and systematic analysis reports to ensure data traceability and compliance with publication and regulatory submission requirements.

 

Animal models of reproductive system diseases, by mimicking hormonal dysregulation, local inflammation, and tissue remodeling, provide a stable and reproducible in vivo experimental platform for investigating the pathogenesis of reproductive disorders and for evaluating pharmacological agents and reproductive intervention strategies.
 

Product List:


Disease Name

Disease model

Details

 Comprehensive model coverage Glioblastoma

U87-MG-luc orthotopic animal model of brain tumor

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 Comprehensive model coverage Alzheimer's disease

Alzheimer’s disease AD animal model

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 Comprehensive model coverage Encephalomyelitis

Allergic encephalomyelitis animal model of AE

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 Comprehensive model coverage Post-traumatic stress disorder

Animal model of post-traumatic stress disorder (PTSD)

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 Comprehensive model coverage Traumatic brain injury

Animal model of traumatic brain injury

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 Comprehensive model coverage Epilepsy

Epilepsy animal model

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 Comprehensive model coverage Spinal cord injury

Animal model of spinal cord injury

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 Comprehensive model coverage Anxiety disorder

Anxiety disorder animal model

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 Comprehensive model coverage Neurological dysfunction after TBI

Animal model of electrical stimulation for traumatic brain injury

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 Comprehensive model coverage Traumatic brain injury

Animal model of traumatic brain injury

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 Comprehensive model coverage Depression

Chronic Unpredictable Mild Stress (CUMS) animal model

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 Comprehensive model coverage Hemorrhagic stroke

Animal model of cerebral hemorrhage

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Cerebral ischemia MCAO animal model

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 Comprehensive model coverage Sepsis-associated encephalopathy

Sepsis-induced brain injury model

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 Comprehensive model coverage Parkinson's disease

Parkinson’s disease animal model

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 Comprehensive model coverage Hepatic encephalopathy (early stage)

Mild hepatic encephalopathy model

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 Comprehensive model coverage Hypoxic-ischemic brain injury

Hypoxic-ischemic encephalopathy (HIE) animal model

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 Comprehensive model coverage Trigeminal neuralgia

Trigeminal neuralgia animal model

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 Comprehensive model coverage Sleep disorder

Animal models of sleep disorders/insomnia

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 Comprehensive model coverage Vascular dementia

Vascular dementia animal model

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 Comprehensive model coverage Depression

Animal model of depression

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 Comprehensive model coverage Multiple sclerosis

Animal model of autoimmune encephalomyelitis

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 Comprehensive model coverage Neuropathic pain

Sciatic nerve compression animal model

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Disease Name

Disease model

Construction method

 Comprehensive model coverage Migraine

Migraine model

Nitroglycerin injection, dural inflammation-induced stimulation (application of inflammatory substances)

 Comprehensive model coverage Hypopituitarism

Pituitaryectomy model

Surgical removal of the pituitary gland (via the transsphenoidal or transcranial approach)

 Comprehensive model coverage Suppurative osteomyelitis

Experimental model of osteomyelitis

Tibial drilling and injection of Staphylococcus aureus

 Comprehensive model coverage Ischemic tolerance induction

Hypoxic preconditioning model

Severe ischemia is induced following repeated brief periods of hypoxic exposure (in normobaric or hypobaric chambers).

 Comprehensive model coverage Vestibular dysfunction

Unilateral labyrinthectomy model

Surgical destruction of the unilateral vestibular organ in rats and guinea pigs.

 Comprehensive model coverage Antipsychotic-induced bone loss

Schizophrenia-induced osteoporosis model

Long-term administration of antipsychotic agents (such as haloperidol) in combination with ovariectomy or glucocorticoid induction

 Comprehensive model coverage Periprosthetic osteolysis

Cranial bone dissolution model

Cranial implantation of titanium particles or inflammatory factors (TNF-α/polyethylene particles)

 Comprehensive model coverage Post-ischemic epilepsy

Global cerebral ischemic epilepsy model

Seizures following bilateral common carotid artery ligation and hypotension-induced ischemia

Disease Name

Disease model

Details

Polycystic Ovary Syndrome (PCOS) Animal Model

Animal model of pregnancy-induced hypertension (PIH)

Endometriosis (EMs) animal model

Spontaneous abortion animal model of SA

Disease Name

Disease model

Construction method

Thin endometrium

Thin uterine model

Mechanical curettage

Chronic Cervicitis

Cervicitis model

Cervical application of phenol mucilage

Testicular torsion injury

Testicular ischemia-reperfusion model

Testicular torsion of 720°

Vasectomy sterilization

Vasectomy model

Inguinal incision for vasectomy

Benign prostatic hyperplasia

Prostatic hyperplasia model

Combined injection of testosterone and estradiol

Premature Ovarian Insufficiency

Ovarian Function Decline Model

Intraperitoneal injection of cyclophosphamide

Pain associated with endometriosis

Endometriosis pain model

Autologous graft lesion + behavioral monitoring

Uterine leiomyoma

Uterine fibroid model

Subcutaneous implantation of estrogen sustained-release tablets