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Custodial breeding and purification

Aniphe BioLab has established an integrated laboratory animal resource platform covering genetic resource preservation, IVF-assisted breeding, SPF rederivation, and managed breeding services, providing full-cycle solutions from long-term genetic preservation to efficient colony expansion.Through sperm and embryo cryopreservation, IVF-ET, and SPF rederivation technologies, we enable secure genetic resource storage, rapid colony expansion, and recovery of contaminated strains. Combined with standardized breeding and husbandry management, our platform ensures process traceability, improves batch consistency and animal supply reliability, and reduces facility operating costs.We provide high-quality, sustainable laboratory animal resources to support academic research and biopharmaceutical development.

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High-Efficiency IVF-ET Rapid Propagation Platform

45-day rapid propagation | Synchronized birth within the same batch | High‑consistency laboratory animal supply system

Aniphe BioLab technology has established a highly efficient IVF‑ET (in vitro fertilization–embryo transfer) assisted reproductive technology platform, focusing on addressing key challenges such as long natural breeding cycles, unstable production capacity, and low strain‑expansion efficiency. This platform enables large‑scale, highly consistent reproduction of laboratory mice within a short timeframe.

By standardizing superovulation protocols, in vitro fertilization, and embryo transfer procedures, the fertilization process is conducted in a controlled external environment. Combined with an SPF‑grade pseudopregnant recipient system, this approach ensures efficient embryonic development and stable birth outcomes.

The platform can achieve:

●Obtain rapidly propagated offspring within 45 days.
●A single male mouse can support large-scale offspring expansion.
●The birth interval among offspring in the same litter is kept within 2–3 days.
●Significantly enhance experimental age synchronization and data consistency.

Technical Advantages:

●Reproductive efficiency has more than doubled.
●1–2 male mice of the correct genotype are sufficient to generate ≥50 offspring.
●Supports ultra-early (3–5 weeks of age) superovulation and multiparous breeding.
●SPF-grade recipient systems ensure the quality of offspring.

●Significantly reduce the natural breeding failure rate.

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Application scenarios:

Rapid expansion of transgenic/knockout mouse colonies

Batch Construction of Pharmacological Efficacy Evaluation Models

Preparation of age-matched experimental animals

Rapid recovery and amplification of valuable strains

Success Stories:

A homozygous mouse of a certain valuable strain:

Project Background:

Older male and female rats have reduced fertility, making it difficult to achieve the desired population through natural reproduction.

Using assisted reproductive technologies:

Using 10 aged homozygous female mice and 1 aged homozygous male mouse, we successfully obtained 51 homozygous target mice for the client.

APC-Min mice with colorectal cancer:

Project Background:

The experiment requires a large number of laboratory mice that are from the same batch, of the same age group, and of the same sex.

Using assisted reproductive technologies:

Using four male mice, we successfully bred 321 offspring.

A homozygous mouse of a certain valuable strain:

Project Background:

Microbial contamination in laboratory mice requires purification and propagation.

Using assisted reproductive technologies:

The company selected nine 4-week-old female mice and two 12-week-old male mice from this strain, successfully bred 59 offspring, and achieved both pathogen clearance and expanded the mouse colony.

Conservation of Genetic Resources and Breed Restoration

Long-term secure storage system for genetic material

We offer sperm and embryo cryopreservation services to safeguard genetic resources, establish a genetic resource bank for laboratory animals, and ensure the long-term stable preservation of strains while isolating them from potential risks.

Sperm cryopreservation / Embryo cryopreservation

Long-term liquid nitrogen storage system

Recovery and Restoration of Genetic Resources

Rats support only an embryo cryopreservation system.

Laboratory Animal Sanitization Services

Polluted strain → SPF standardized recovery system

Through purification techniques such as embryo transfer, strains that are contaminated or exhibit unstable phenotypes can be restored to the SPF standard for laboratory animals.

Placental Barrier Purification Technology

Pathogen Clearance and Population Recovery
SPF Level Reconstruction
Verification of Genetic Background Stability

Value:

Restore precious contaminated strains

Meets GLP/SPF experimental standards

Enhance model compliance

Custodial Platform for Contract Breeding and Reproduction

SPF Animal Center Hosting System

We offer standardized SPF animal facility services for colony maintenance and breeding, enabling full‑life‑cycle management and a traceability system for laboratory animals.

SPF-grade animal facility contract breeding

Model Rodent Reproduction and Population Management

The entire breeding process is traceable.

Real-time status monitoring