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Oral disease models

Aniphe BioLab develops oral disease models based on key pathological mechanisms, including oral microenvironment dysregulation, bacterial infection, and inflammatory responses. These models support in vivo research on periodontitis, oral ulcers, pulpitis, and inflammatory diseases of the jawbone.
By reproducing local microbial dysbiosis, inflammatory cytokine release, and tissue damage, our models provide reliable platforms for disease mechanism studies and drug evaluation. Applications include anti-inflammatory and antimicrobial therapies, oral restorative materials, periodontal tissue regeneration, and local immune regulation.

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Mechanism-oriented
Precision Modeling

Multiple reviews
System Verification

Phenotypic stability
Repeatability

University Support
Accelerate R&D

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Characteristics of Oral Disease Models from Aniphe BioLab

In response to the research needs surrounding dysregulation of the oral microenvironment and inflammatory injury,Aniphe BioLab has established a standardized animal model system for oral-related diseases, characterized by the following key features:

Comprehensive model coverage

Comprehensive coverage of model types

It encompasses common disease models such as periodontitis, oral ulcers, pulpitis, and mandibular osteomyelitis, meeting the needs of both basic research and pharmacological efficacy evaluation.

Standardization of the modeling process

Standardization of the modeling process

Standardize the modeling method, stimulus intensity, and local treatment protocol to minimize the impact of procedural variability on experimental outcomes.

Multidimensional Evaluation System

Multidimensional Evaluation System

By integrating histopathological analysis, inflammatory cytokine assays, and assessments of local structural changes, a comprehensive evaluation of inflammation and tissue damage can be achieved.

Standardization of Data Delivery

Standardization of Data Delivery

Provide raw experimental data, pathological images, and analytical results to ensure data traceability and compliance with publication and regulatory submission requirements.

Animal models of oral diseases, by mimicking local inflammation and tissue destruction, provide a stable and reproducible in vivo experimental platform for investigating the pathogenesis of oral disorders and for evaluating drugs and biomaterials.

Product List:

Disease Name	Disease model	Details
Glioblastoma	U87-MG-luc orthotopic animal model	View details →
Alzheimer's disease	Alzheimer’s disease AD animal model	View details →
Encephalomyelitis	Animal model of allergic encephalomyelitis (AE)	View details →
Post-traumatic stress disorder	Animal model of post-traumatic stress disorder (PTSD)	View details →
Traumatic brain injury	Animal model of traumatic brain injury	View details →
Epilepsy	Epilepsy animal model	View details →
Spinal cord injury	Animal model of spinal cord injury	View details →
Anxiety disorder	Anxiety disorder animal model	View details →
Neurological dysfunction after TBI	Animal model of electrical stimulation for traumatic brain injury	View details →
Traumatic brain injury	Animal model of traumatic brain injury	View details →
Depression	Chronic Unpredictable Mild Stress (CUMS) animal model	View details →
Hemorrhagic stroke	Animal model of cerebral hemorrhage	View details →
	Cerebral ischemia MCAO animal model	View details →
Sepsis-associated encephalopathy	Sepsis-induced brain injury model	View details →
Parkinson's disease	Parkinson’s disease animal model	View details →
Hepatic encephalopathy (early stage)	Mild hepatic encephalopathy model	View details →
Hypoxic-ischemic brain injury	Hypoxic-ischemic encephalopathy (HIE) animal model	View details →
Trigeminal neuralgia	Trigeminal neuralgia animal model	View details →
Sleep disorder	Animal models of sleep disorders/insomnia	View details →
Vascular dementia	Vascular dementia animal model	View details →
Depression	Animal model of depression	View details →
Multiple sclerosis	Animal model of autoimmune encephalomyelitis	View details →
Neuropathic pain	Sciatic nerve compression animal model	View details →

Disease Name	Disease model	Construction method
Migraine	Migraine model	Nitroglycerin injection, dural inflammation-induced stimulation (application of inflammatory substances)
Hypopituitarism	Pituitaryectomy model	Surgical removal of the pituitary gland (via the transsphenoidal or transcranial approach)
Suppurative osteomyelitis	Experimental model of osteomyelitis	Tibial drilling and injection of Staphylococcus aureus
Ischemic tolerance induction	Hypoxic preconditioning model	Severe ischemia induced after repeated short-term hypoxic exposures (in normobaric or hypobaric chambers)
Vestibular dysfunction	Unilateral labyrinthectomy model	Surgical destruction of the unilateral vestibular organ in rats and guinea pigs.
Antipsychotic-induced bone loss	Schizophrenia-induced osteoporosis model	Long-term administration of antipsychotic agents (such as haloperidol) in combination with ovariectomy or glucocorticoid induction
Periprosthetic osteolysis	Cranial bone dissolution model	Cranial implantation of titanium particles or inflammatory factors (TNF-α/polyethylene particles)
Post-ischemic epilepsy	Global cerebral ischemic epilepsy model	Seizures following bilateral common carotid artery ligation combined with hypotension-induced ischemia

Disease Name

Disease model

Details

Recurrent oral ulcers

Oral Ulcer OU Animal Model

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Optimization of the Forming Process for Clear Aligners

Orthodontic OTM animal model

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Chronic periodontitis

Periodontitis PD animal model

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Disease Name	Disease model	Construction method
Recurrent oral ulcers	Oral ulcer model	Chemical cauterization, immunological methods
Allergic rhinitis	Allergic Rhinitis Model	Intraperitoneal injection and intranasal administration of ovalbumin (OVA)
Tympanic membrane perforation and hearing impairment	Tympanic Membrane Perforation Model	Surgical perforation method