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Bone-related disease model
Aniphe BioLab develops bone and skeletal disease models based on established disease mechanisms and standardized modeling protocols, supporting research on bone metabolic disorders, inflammatory bone destruction, and skeletal degeneration.
By reproducing imbalances in bone resorption and formation, articular cartilage degeneration, and inflammatory microenvironment changes, our models provide reliable in vivo platforms for disease mechanism studies and drug evaluation. Applications include orthopedic drug development, anti-inflammatory drug evaluation, and bone regenerative material research, particularly in osteoporosis, osteoarthritis, and rheumatoid arthritis.
Precision Modeling
System Verification
Repeatability
Accelerate R&D
Related Resources
Characteristics of Aniphe BioLab Bone-Related Disease Models
Leveraging a standardized animal model platform and extensive experience in long-term pharmacological efficacy evaluation, Jiangsu Ailingfei Biotechnology Co., Ltd. has established a systematic, reproducible, and scalable animal model system for bone-related diseases, tailored to research needs in this field, with the following key features:
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We offer mainstream disease models, including osteoporosis, osteoarthritis, and rheumatoid arthritis, to meet the needs of mechanistic research and drug efficacy evaluation. |
Standardized SOP-based process management ensures consistent data across batches by standardizing every step, from animal selection and model‑generation methods to sampling time points. |
Supports a three-tiered assessment of bone structure, inflammation, and function, including: micro-CT–based bone structural analysis, histopathological examination (e.g., H&E, TRAP), inflammatory cytokine assays, and behavioral and pain assessments. |
We provide raw data, imaging results, and standardized reports to meet the requirements for manuscript publication and grant applications. |
The animal model system for diseases related to the alveolar bone, with a focus on stability, reproducibility, and translational efficacy, provides a reliable experimental foundation for orthopedic drug development and mechanistic studies.
Product List:
Disease Name
Disease model
Details
Animal model of avascular necrosis of the femoral head
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Disease Name |
Disease model |
Construction method |
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Muscle injury/hematoma |
Rat blunt muscle contusion model |
Pneumatic impactor striking the quadriceps femoris muscle |
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Complete spinal cord injury |
Spinal cord hemisection model |
Laminectomy at T9–T10 combined with hemisection of the spinal cord |
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Gout model |
Gouty Arthritis Model |
Resection of an 8-mm segment of the midshaft of the tibia. |
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Bone Regeneration Assessment |
Femoral Diaphyseal Bone Defect Model |
Femoral ankle drilling |
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Meniscus tear |
Full-thickness meniscal injury model |
Longitudinal full-thickness incision of the meniscal body |
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Hyperthyroidism |
Hyperthyroidism model |
Levothyroxine gavage |
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Ankylosing spondylitis |
Ankylosing spondylitis model |
Spontaneous inflammation driven by the immune-genetic–gut–joint axis |
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TNF-Mut Arthritis |
TNF-α transgenic arthritis model |
Joint destruction driven by a single inflammatory cytokine (TNF) |
Aniphe BioLab Inc.
Address:
Runcheng, No. 8 Longtai Road, Jiangbei New Area, Nanjing City, Jiangsu Province
Building 8, Science Park
Postal Code: 210007
Phone:025-8520 8061
Email:info@aniphebio.com(Consultation)
Email:order@aniphebio.com(Order)
WeChat Official Account
Video Account
Su Public Security Bureau Internet Information Service Filing No. 32010402001421