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Psychiatric & neurological disease models

Aniphe BioLab has established an integrated laboratory animal resource platform covering genetic resource preservation, IVF-assisted breeding, SPF rederivation, and managed breeding services, providing full-cycle solutions from long-term genetic preservation to efficient colony expansion.Through sperm and embryo cryopreservation, IVF-ET, and SPF rederivation technologies, we enable secure genetic resource storage, rapid colony expansion, and recovery of contaminated strains. Combined with standardized breeding and husbandry management, our platform ensures process traceability, improves batch consistency and animal supply reliability, and reduces facility operating costs.We provide high-quality, sustainable laboratory animal resources to support academic research and biopharmaceutical development.

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Mechanism-oriented
Precision Modeling

Multiple reviews
System Verification

Phenotypic stability
Repeatability

University Support
Accelerate R&D

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Psychiatric & neurological disease models

Cardiovascular disease model

Respiratory disease model

Endocrine and Immune system models

Digestive system models

Urinary system disease model

Bone-related disease model

Oral disease models

Reproductive system disease model

Skin-related disease models

Animal models of other diseases

Characteristics of Aniphe BioLab Models for Mental and Neurological Disorders

In response to the complexity of central nervous system disease research and the need for multidimensional evaluation, Ailinfei Biotechnology has established a standardized animal model platform that encompasses behavioral assays, molecular mechanisms, and pathology, ensuring model stability and data consistency.

Comprehensive model coverage

Comprehensive model coverage

It encompasses mainstream neuropsychiatric disease models, including depression, anxiety, schizophrenia, and cognitive disorders, thereby meeting the needs of different stages of research.

Standardization of the modeling process

Standardization of the modeling process

Standardize stress‑induction protocols and experimental timelines to minimize confounding effects from behavioral and environmental factors.

Multidimensional Evaluation System

Multidimensional Evaluation System

By integrating behavioral outcomes, neurotransmitter alterations, and brain tissue pathology, we achieve a simultaneous assessment of function and underlying mechanisms.

Standardization of Data Delivery

Standardization of Data Delivery

Provide raw behavioral data, imaging records, and analysis results to ensure the traceability of experimental outcomes.

Such models, by integrating behavioral phenotyping with central nervous system mechanisms, provide a stable and reproducible in vivo experimental platform for drug screening and mechanistic studies of psychiatric and neurological disorders.

Product List:

Disease Name	Disease model	Details
Glioblastoma	U87-MG-luc orthotopic animal model	View details →
Alzheimer's disease	Alzheimer’s disease AD animal model	View details →
Encephalomyelitis	Allergic encephalomyelitis animal model of AE	View details →
Post-traumatic stress disorder	Animal model of post-traumatic stress disorder (PTSD)	View details →
Traumatic brain injury	Animal model of traumatic brain injury	View details →
Epilepsy	Epilepsy animal model	View details →
Spinal cord injury	Animal model of spinal cord injury	View details →
Anxiety disorder	Anxiety disorder animal model	View details →
Neurological dysfunction after TBI	Animal model of traumatic brain injury induced by electrical stimulation	View details →
Traumatic brain injury	Animal model of traumatic brain injury	View details →
Depression	Chronic Unpredictable Mild Stress (CUMS) animal model	View details →
Hemorrhagic stroke	Animal model of cerebral hemorrhage	View details →
	Cerebral ischemia MCAO animal model	View details →
Sepsis-associated encephalopathy	Sepsis-induced brain injury model	View details →
Parkinson's disease	Parkinson’s disease animal model	View details →
Hepatic encephalopathy (early stage)	Mild hepatic encephalopathy model	View details →
Hypoxic-ischemic brain injury	Hypoxic-ischemic encephalopathy (HIE) animal model	View details →
Trigeminal neuralgia	Trigeminal neuralgia animal model	View details →
Sleep disorder	Animal models of sleep disorders/insomnia	View details →
Vascular dementia	Vascular dementia animal model	View details →
Depression	Animal model of depression	View details →
Multiple sclerosis	Animal model of autoimmune encephalomyelitis	View details →
Neuropathic pain	Sciatic nerve compression animal model	View details →

Disease Name	Disease model	Construction method
Migraine	Migraine model	Nitroglycerin injection, dural inflammation-induced stimulation (application of inflammatory substances)
Hypopituitarism	Pituitaryectomy model	Surgical removal of the pituitary gland (via the transsphenoidal or transcranial approach)
Suppurative osteomyelitis	Experimental model of osteomyelitis	Tibial drilling and injection of Staphylococcus aureus
Ischemic tolerance induction	Hypoxic preconditioning model	Severe ischemia induced after repeated short-term hypoxic exposures (in normobaric or hypobaric chambers)
Vestibular dysfunction	Unilateral labyrinthectomy model	Surgical destruction of the unilateral vestibular organ in rats and guinea pigs.
Antipsychotic-induced bone loss	Schizophrenia-induced osteoporosis model	Long-term administration of antipsychotic agents (such as haloperidol) in combination with ovariectomy or glucocorticoid induction
Periprosthetic osteolysis	Cranial bone dissolution model	Cranial implantation of titanium particles or inflammatory factors (TNF-α/polyethylene particles)
Post-ischemic epilepsy	Global cerebral ischemic epilepsy model	Seizures following bilateral common carotid artery ligation combined with hypotension-induced ischemia

Disease Name

Disease model

Details

Glioblastoma123

U87-MG-luc orthotopic animal model

Disease Name	Disease model	Construction method
Migraine	Migraine model	Nitroglycerin injection, dural inflammation-induced stimulation (application of inflammatory substances)
Hypopituitarism	Pituitaryectomy model	Surgical removal of the pituitary gland (via the transsphenoidal or transcranial approach)
Suppurative osteomyelitis	Experimental model of osteomyelitis	Tibial drilling and injection of Staphylococcus aureus
Ischemic tolerance induction	Hypoxic preconditioning model	Severe ischemia induced after repeated short-term hypoxic exposures (in normobaric or hypobaric chambers)
Vestibular dysfunction	Unilateral labyrinthectomy model	Surgical destruction of the unilateral vestibular apparatus in rats and guinea pigs.
Antipsychotic-induced bone loss	Schizophrenia-induced osteoporosis model	Long-term administration of antipsychotic agents (such as haloperidol) in combination with ovariectomy or glucocorticoid induction
Periprosthetic osteolysis	Cranial bone dissolution model	Cranial implantation of titanium particles or inflammatory factors (TNF-α/polyethylene particles)
Post-ischemic epilepsy	Global cerebral ischemic epilepsy model	Seizures following bilateral common carotid artery ligation and hypotension-induced ischemia

Characteristics of Aniphe BioLab Models for Mental and Neurological Disorders

Product List:

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