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Respiratory disease model
Aniphe BioLab develops respiratory disease models based on key pathological processes, including pulmonary inflammation, airway remodeling, and fibrosis. These models support in vivo research on asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, and acute lung injury (ALI).
Through external stimuli or immune induction, our models reproduce key disease features, including airway hyperresponsiveness, inflammatory cell infiltration, and structural changes in lung tissue. They provide reliable platforms for disease mechanism studies and drug screening, supporting the development of anti-inflammatory, bronchodilatory, and antifibrotic therapies, as well as research on lung injury repair and related signaling pathways.
Precision Modeling
System Verification
Repeatability
Accelerate R&D
Related Resources
Characteristics of Aniphe BioLab's Respiratory Disease Models
Addressing the real-world experimental needs in respiratory disease research, Aniphe BioLab has established a standardized framework encompassing modeling, evaluation, and data delivery, ensuring high consistency and comparability of models across different batches and projects.
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It encompasses mainstream disease models such as asthma, COPD, pulmonary fibrosis, and acute lung injury, covering the entire research spectrum from inflammatory responses to structural remodeling. |
Standardized management of sensitization methods, stimulus intensity, and dosing schedules is implemented to minimize experimental bias arising from human error. |
By integrating pulmonary function, inflammatory markers, and BALF parameters, a comprehensive assessment spanning from histomorphological changes to functional alterations can be achieved. |
Raw experimental data, imaging results, and analysis files are systematically archived to ensure traceability and meet the requirements for publication and regulatory submissions. |
The core value of respiratory disease models lies in faithfully recapitulating the sequential pathological cascade of airway–inflammation–structural remodeling. By employing standardized modeling and rigorous consistency control, Aniphe BioLab provides a stable and reliable in vivo experimental platform for respiratory drug discovery and mechanistic studies.
Product List:
Disease Name
Disease model
Details
Chronic Obstructive Pulmonary Disease (COPD) Animal Model
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Disease Name |
Disease model |
Construction method |
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Neonatal respiratory distress syndrome |
Respiratory distress model |
Intraperitoneal injection of LPS in neonatal rats |
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Reperfusion injury after lung transplantation |
Pulmonary ischemia-reperfusion model |
Surgical occlusion of the left pulmonary hilum for 30 minutes followed by 2 hours of reperfusion. |
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Cardiogenic/Non-cardiogenic Pulmonary Edema |
Pulmonary edema model |
Adrenaline injection, seawater inhalation |
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Bronchopulmonary dysplasia in preterm infants |
Bronchopulmonary dysplasia model |
Hyperoxia exposure |
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Pulmonary Venous Occlusive Disease |
Pulmonary vein occlusion model |
Pulmonary arterial hypertension induced by monocrotaline injection |
Aniphe BioLab Inc.
Address:
Runcheng, No. 8 Longtai Road, Jiangbei New Area, Nanjing City, Jiangsu Province
Building 8, Science Park
Postal Code: 210007
Phone:025-8520 8061
Email:info@aniphebio.com(Consultation)
Email:order@aniphebio.com(Order)
WeChat Official Account
Video Account
Su Public Security Bureau Internet Information Service Filing No. 32010402001421