All

All
Insight
Research Services
Preclinical CRO
Animal Resource Bank

Digestive system models

Aniphe BioLab develops digestive system disease models based on key pathological mechanisms, including gastrointestinal mucosal barrier damage, inflammatory imbalance, gut microbiota dysbiosis, and impaired tissue repair. These models support in vivo research on gastritis, gastric ulcers, inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's-like disease, intestinal mucosal injury, and hepatobiliary inflammatory diseases.
By reproducing chemical or immune-mediated injury, gut microbiota dysbiosis, and inflammatory cytokine cascades, our models provide reliable platforms for disease mechanism studies and drug evaluation. Applications include anti-inflammatory agents, gastrointestinal mucosal protectants, immunomodulators, and microbiota-based interventions, as well as research on intestinal immune regulation and mucosal repair.

Explore more

Mechanism-oriented
Precision Modeling

Multiple reviews
System Verification

Phenotypic stability
Repeatability

University Support
Accelerate R&D

Related Resources

Psychiatric & neurological disease models

Cardiovascular disease model

Respiratory disease model

Endocrine and Immune system models

Digestive system models

Urinary system disease model

Bone-related disease model

Oral disease models

Reproductive system disease model

Skin-related disease models

Animal models of other diseases

Characteristics of Aniphe BioLab's Digestive System Disease Models

In response to the research needs surrounding gastrointestinal barrier dysfunction and dysregulated immune-inflammatory responses, Aniphe BioLab has established a standardized animal model system for digestive system diseases, characterized by the following key features:

Comprehensive model coverage

Comprehensive coverage of model types

It encompasses models of acute and chronic gastritis, gastric ulcers, ulcerative colitis, intestinal barrier dysfunction, and hepatobiliary inflammation, meeting the needs of basic research and pharmacological efficacy evaluation in the digestive system.

Standardization of the modeling process

Standardization of the modeling process

Standard operating procedures (SOPs) are implemented to standardize modeling approaches, including chemical induction, immune induction, and microbial/microbiota interventions, thereby reducing inter‑batch variability.

Multidimensional Evaluation System

Multidimensional Evaluation System

By integrating histopathological scoring, inflammatory cytokine assays, intestinal barrier function markers, and microbiota composition analysis, a comprehensive assessment of both structural and functional parameters is achieved.

Standardization of Data Delivery

Standardization of Data Delivery

We provide raw experimental data, pathology slide images, functional assay results, and statistical analysis reports, ensuring data integrity and traceability while meeting the requirements for publication and regulatory submissions.

Animal models of gastrointestinal diseases, by mimicking the disruption of the gastrointestinal barrier and the dysregulation of immune‑inflammatory homeostasis, provide a stable and reproducible in vivo experimental platform for investigating disease mechanisms and evaluating pharmacological and microbiota‑based intervention strategies.

Product List:

Disease Name	Disease model	Details
Glioblastoma	U87-MG-luc orthotopic animal model	View details →
Alzheimer's disease	Alzheimer’s disease AD animal model	View details →
Encephalomyelitis	Allergic encephalomyelitis animal model of AE	View details →
Post-traumatic stress disorder	Animal model of post-traumatic stress disorder (PTSD)	View details →
Traumatic brain injury	Animal model of traumatic brain injury	View details →
Epilepsy	Epilepsy animal model	View details →
Spinal cord injury	Animal model of spinal cord injury	View details →
Anxiety disorder	Anxiety disorder animal model	View details →
Neurological dysfunction after TBI	Animal model of electrical stimulation for traumatic brain injury	View details →
Traumatic brain injury	Animal model of traumatic brain injury	View details →
Depression	Chronic Unpredictable Mild Stress (CUMS) animal model	View details →
Hemorrhagic stroke	Animal model of cerebral hemorrhage	View details →
	Cerebral ischemia MCAO animal model	View details →
Sepsis-associated encephalopathy	Sepsis-induced brain injury model	View details →
Parkinson's disease	Parkinson’s disease animal model	View details →
Hepatic encephalopathy (early stage)	Mild hepatic encephalopathy model	View details →
Hypoxic-ischemic brain injury	Hypoxic-ischemic encephalopathy (HIE) animal model	View details →
Trigeminal neuralgia	Trigeminal neuralgia animal model	View details →
Sleep disorder	Animal models of sleep disorders/insomnia	View details →
Vascular dementia	Vascular dementia animal model	View details →
Depression	Animal model of depression	View details →
Multiple sclerosis	Animal model of autoimmune encephalomyelitis	View details →
Neuropathic pain	Sciatic nerve compression animal model	View details →

Disease Name	Disease model	Construction method
Migraine	Migraine model	Nitroglycerin injection, dural inflammation-induced stimulation (application of inflammatory substances)
Hypopituitarism	Pituitaryectomy model	Surgical removal of the pituitary gland (via the transsphenoidal or transcranial approach)
Suppurative osteomyelitis	Experimental model of osteomyelitis	Tibial drilling and injection of Staphylococcus aureus
Ischemic tolerance induction	Hypoxic preconditioning model	Severe ischemia is induced following repeated brief periods of hypoxic exposure (in normobaric or hypobaric chambers).
Vestibular dysfunction	Unilateral labyrinthectomy model	Surgical destruction of the unilateral vestibular organ in rats and guinea pigs.
Antipsychotic-induced bone loss	Schizophrenia-induced osteoporosis model	Long-term administration of antipsychotic agents (such as haloperidol) in combination with ovariectomy or glucocorticoid induction
Periprosthetic osteolysis	Cranial bone dissolution model	Cranial implantation of titanium particles or inflammatory factors (TNF-α/polyethylene particles)
Post-ischemic epilepsy	Global cerebral ischemic epilepsy model	Seizures following bilateral common carotid artery ligation and hypotension-induced ischemia

Disease Name

Disease model

Details

Irritable Bowel Syndrome

Irritable Bowel Syndrome IBS Animal Model

Disease Name	Disease model	Construction method
Chronic pancreatitis	Chronic pancreatitis model	Repeated injection of rainfrog peptide (6–8 weeks), DBTC injection into the bile and pancreatic ducts
Gastroesophageal Reflux Disease	Reflux Esophagitis Model	Partial pyloric ligation with cardia myotomy
Intestinal Failure–Related Liver Disease	Parenteral Nutrition Model	Central venous catheterization for continuous infusion of total parenteral nutrition (TPN) for ≥7 days
Postoperative intestinal repair	Small intestinal anastomosis model	Surgical transection of the small intestine followed by end-to-end or side-to-side anastomosis.
Postoperative intra-abdominal adhesions	Small intestinal adhesion model	Cecal serosal abrasion plus abdominal wall defect closure
Mechanical intestinal obstruction	Intestinal obstruction model	Surgical ligation of the distal ileum resulted in complete obstruction.
Traumatic intestinal injury of the abdomen	Abdominal Impact–Induced Intestinal Injury Model	Controlled-Impact-Pressure Instrument (CII) for Quantitative Abdominal Impact
Bile Acid Metabolism Research	Bile Flow Model	Choledochoduodenal side-to-side anastomosis (biliary diversion)
Mesenteric Ischemia/Shock	Small intestinal ischemia-reperfusion model	Clamp the superior mesenteric artery for 45 minutes, then release it.
Eosinophilic gastroenteritis	Eosinophilic Gastroenteritis Model	Oral OVA sensitization combined with multiple intraperitoneal injections of IL-5/CCL11 (to induce eosinophil infiltration)
Chronic non-healing ulcer	Chronic ulcer model in rats	Local injection of acetic acid into the gastric wall (resulting in submucosal necrosis)
Research on genetically related diseases	Gene-editing model	Using CRISPR technology to generate animals with specific gene knockouts, such as ApoE−/− mice.

Characteristics of Aniphe BioLab's Digestive System Disease Models

Product List:

Aniphe BioLab Inc.