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Focusing on cutting-edge technologies and research advancements,
sharing Aniphe BioLab’s achievements in scientific innovation, Professional insights
and practical experience in the fields of laboratory animals and preclinical research.

Literature Review | New Advances in Alzheimer’s Disease Research—Turns Out It May Not Be Related to β-Amyloid?
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2022/12/19

Literature Review | New Advances in Alzheimer’s Disease Research—Turns Out It May Not Be Related to β-Amyloid?

On June 2 this year, an article titled “Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques” generated considerable attention, suggesting that the pathogenic factors underlying Alzheimer’s disease may extend beyond β‑amyloid alone.

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Essential Tips | Second Installment on Raising Old-Aged Mice
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2022/12/19

Essential Tips | Second Installment on Raising Old-Aged Mice

The second installment of the Senior Rat Q&A is here!

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Literature Interpretation | APOE4 does not depend on β‑amyloid deposition; instead, it accelerates late‑stage vascular alterations and neurodegeneration in aged AD mouse models via cyclophilin A.
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2022/12/16

Literature Interpretation | APOE4 does not depend on β‑amyloid deposition; instead, it accelerates late‑stage vascular alterations and neurodegeneration in aged AD mouse models via cyclophilin A.

Apolipoprotein E4 (APOE4) is a major genetic risk factor for Alzheimer’s disease (AD), and it contributes to vascular dysfunction, amyloid‑β pathology, neurodegeneration, and dementia. However, the underlying pathogenic mechanisms remain unclear.

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Literature Interpretation | Spatial Transcriptomic Sequencing Analysis of Acute Kidney Injury in Mice
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2022/12/16

Literature Interpretation | Spatial Transcriptomic Sequencing Analysis of Acute Kidney Injury in Mice

Acute Kidney Injury (AKI): Refers to a sudden decline in renal function that occurs within 1–7 days and persists for more than 24 hours, characterized by an increase in serum creatinine (SCr) of at least 0.5 mg/dL. It manifests as azotemia, disturbances in fluid, electrolyte, and acid–base balance, accompanied by oliguria (<400 mL/24 h or 17 mL/h) or anuria (<100 mL/24 h), along with systemic symptoms.

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Literature Review | Latest Research: Exploring the Pathogenesis of Cardiac Fibrosis Through Gene-Edited Pigs!
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2022/12/16

Literature Review | Latest Research: Exploring the Pathogenesis of Cardiac Fibrosis Through Gene-Edited Pigs!

Mutations in the MYBPC3 gene, which encodes cardiac myosin-binding protein C (cMyBP-C), are the most common cause of hypertrophic cardiomyopathy (HCM). Myocardial fibrosis (MF) plays a critical role in the pathogenesis and progression of HCM. However, the mechanisms by which MYBPC3 mutations induce MF remain unclear. In this study, the researchers employed cytosine base‑editing technology to generate a porcine model carrying the R495Q mutation and observed early‑onset myocardial fibrosis shortly after birth in these mutant pigs.

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Literature Review | Mouse Stroke Model: High-Resolution Micro-CT Imaging—From Infarct Characterization to Automated Region Segmentation
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2022/12/15

Literature Review | Mouse Stroke Model: High-Resolution Micro-CT Imaging—From Infarct Characterization to Automated Region Segmentation

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Mouse Classroom | With so many AD models, what are the differences?
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2022/12/15

Mouse Classroom | With so many AD models, what are the differences?

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Key Insights | What Are the Animal Models of Rheumatoid Arthritis?
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2022/12/15

Key Insights | What Are the Animal Models of Rheumatoid Arthritis?

Rheumatoid arthritis (RA) is a common autoimmune disease with a high disability rate, yet its pathogenic mechanisms remain unclear. Establishing appropriate animal models—particularly those that closely mimic the human disease—is of paramount importance for elucidating RA’s pathogenesis and developing effective clinical therapies. This issue’s literature review will introduce you to animal models of rheumatoid arthritis.

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