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Focusing on cutting-edge technologies and research advancements,
sharing Aniphe BioLab’s achievements in scientific innovation, Professional insights
and practical experience in the fields of laboratory animals and preclinical research.

Chronic Stress-Induced Depression Model Platform: CUMS/CSDS/CRS/SIS—customizable on demand, supporting the development of novel therapeutics for psychiatric disorders.
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2026/05/29

Chronic Stress-Induced Depression Model Platform: CUMS/CSDS/CRS/SIS—customizable on demand, supporting the development of novel therapeutics for psychiatric disorders.

Depression is a common mental disorder whose principal clinical features include anhedonia, diminished motivation, cognitive deficits, and depressed mood. Genetic factors account for approximately 40% of depressive cases, with the remainder attributable to environmental influences. Chronic stress responses triggered by environmental risk factors can mediate the development of depression. To better elucidate the pathophysiological mechanisms of depression and to identify therapeutic strategies, it is essential to establish an effective animal model of the disorder.

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High‑Throughput MASH Animal Model Platform: Ready‑to‑Ship Solutions Empowering Rapid Preclinical Efficacy Assessment of Novel Therapeutics for Metabolic Diseases
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2026/05/27

High‑Throughput MASH Animal Model Platform: Ready‑to‑Ship Solutions Empowering Rapid Preclinical Efficacy Assessment of Novel Therapeutics for Metabolic Diseases

Colleagues engaged in research and development in the field of metabolic diseases are well aware that, according to the consensus of the International Association for the Study of Liver Diseases, NASH (non‑alcoholic steatohepatitis) has been officially renamed MASH (metabolic dysfunction‑associated steatohepatitis). In our work on in vivo efficacy validation for MASH, the time required to establish the disease model is a critical factor—potentially even determining whether we can graduate on schedule.

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Science: How to Perform “Genetic Screening” on Astrocytes? In Vivo Single-Cell Library Screening Technology
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2026/05/23

Science: How to Perform “Genetic Screening” on Astrocytes? In Vivo Single-Cell Library Screening Technology

The integration of single-cell RNA sequencing (scRNA-seq) with CRISPR‑based screening—known as Perturb‑seq—has revolutionized how we dissect gene function. However, in the context of intact, living tissues, efficiently and at scale investigating gain-of-function (GOF) effects remains fraught with technical challenges.

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Science: How to Perform “Genetic Screening” on Astrocytes? In Vivo Single-Cell Library Screening Technology
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2026/05/23

Science: How to Perform “Genetic Screening” on Astrocytes? In Vivo Single-Cell Library Screening Technology

The integration of single-cell transcriptomics (scRNA-seq) with CRISPR‑based screening—known as Perturb‑seq—has revolutionized how we dissect gene function. However, in the context of intact, living tissues, efficiently and at scale investigating gain-of-function (GOF) effects remains fraught with technical challenges.

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Breakthrough: Successfully established an in vivo neuronal model of Alzheimer’s disease derived from iPSCs that spontaneously forms neurofibrillary tangles.
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2026/05/20

Breakthrough: Successfully established an in vivo neuronal model of Alzheimer’s disease derived from iPSCs that spontaneously forms neurofibrillary tangles.

Tau protein primarily functions to stabilize the microtubule network within neurons. During transcription of the human MAPT (tau protein) gene, alternative splicing of exon 10 gives rise to multiple isoforms: 3R tau, which is produced from transcripts lacking exon 10 and contains three microtubule-binding repeats; and 4R tau, which results from inclusion of this exon and contains four repeats.

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Breakthrough: Successfully established an in vivo neuronal model of Alzheimer’s disease derived from iPSCs that spontaneously forms neurofibrillary tangles.
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2026/05/20

Breakthrough: Successfully established an in vivo neuronal model of Alzheimer’s disease derived from iPSCs that spontaneously forms neurofibrillary tangles.

Tau protein primarily functions to stabilize the microtubule network within neurons. During transcription of the human MAPT (tau protein) gene, alternative splicing of exon 10 gives rise to multiple isoforms: 3R tau, which lacks exon 10 and encodes a transcript containing three microtubule-binding repeats; and 4R tau, which includes this exon and encodes a transcript with four repeats.

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A Novel Mechanism of Immunotherapy for Alzheimer’s Disease: Microglia-Mediated Targeted Clearance of Amyloid Plaques
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2026/05/15

A Novel Mechanism of Immunotherapy for Alzheimer’s Disease: Microglia-Mediated Targeted Clearance of Amyloid Plaques

The plaque‑clearing efficacy of amyloid‑targeted immunotherapies is highly dependent on microglial activation, yet this mechanism had previously lacked robust empirical support. At the recent International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD) held in Copenhagen, Denmark, several studies have helped to fill this critical gap in our understanding of the underlying mechanisms.

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A Novel Mechanism of Immunotherapy for Alzheimer’s Disease: Microglia-Mediated Targeted Clearance of Amyloid Plaques
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2026/05/15

A Novel Mechanism of Immunotherapy for Alzheimer’s Disease: Microglia-Mediated Targeted Clearance of Amyloid Plaques

The plaque‑clearing efficacy of amyloid‑targeting immunotherapies is highly dependent on microglial activation, yet this mechanism has previously lacked robust empirical support. At the recent Alzheimer’s & Parkinson’s Disease (AD/PD) International Conference held in Copenhagen, Denmark, several studies have helped to fill this critical gap in our understanding of the underlying mechanisms.

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