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Pharmacodynamics and Disease Model Research

Verifying a drug’s efficacy is the cornerstone of preclinical evaluation. Aniphe Biolaboratory boasts an extensive library of model mice and extensive expertise in establishing inducible disease models:

In Vivo Animal Model Repository:

Genetically edited mouse models: We offer a range of models, including 5xFAD, APP/PS1, various whole-body or conditional knockouts (KO/cKO), knock-ins (KI), and humanized mouse models.

Spontaneous/Induced Disease Models: These encompass metabolic disorders (such as MASH/NASH—metabolic dysfunction‑associated steatohepatitis, obesity, and diabetes), neurodegenerative diseases (including Alzheimer’s disease [AD] and Parkinson’s disease [PD]), cardiovascular conditions (such as myocardial infarction and pulmonary arterial hypertension [PAH]), as well as cancer immunology (CDX/PDX models).

Natural aging model: Long-term availability and stable supply of aged mouse models aged 18 months and older, with a comprehensive suite of behavioral and biochemical assays.

Precision Pharmacodynamic Characterization Technologies: Equipped with a specialized small-animal imaging team, we offer high-resolution ultrasound imaging (ECHO—e.g., assessment of cardiac functional parameters and observation of the “D-shaped” left ventricular sign indicative of pulmonary hypertension), MRI, micro-CT, as well as comprehensive behavioral assessments in small animals.

Assisted Reproductive Technology (IVF): For valuable or endangered mouse strains, we offer in vitro fertilization (IVF), breeding optimization, and rapid colony expansion services.

In Vitro Evaluation: Conduct routine and complex assays for cell proliferation, apoptosis, signaling pathway analysis, and enzyme activity measurement.