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Animal model of traumatic brain injury

Animal model of traumatic brain injury

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Traumatic brain injury
Psychiatric & neurological disease models

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Model Introduction

Model Introduction

Platform Service Advantages

Platform Service Advantages

Model Construction

Model Construction

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Traumatic brain injury

Introduction to Animal Models of Traumatic Brain Injury

Animal models of traumatic brain injury can replicate chronic, recurrent, and acute disturbances of brain function, with the hallmark being abnormal high-frequency neuronal discharges that propagate to adjacent brain tissue. In addition to abrupt neurological deficits, these models exhibit behavioral abnormalities, motor impairments, and cognitive dysfunction; histopathological changes such as structural damage and inflammatory responses are also observable in the brain. Consequently, they are well suited for investigating underlying pathogenic mechanisms and for evaluating the efficacy of pharmacological agents and therapeutic interventions.

Service Advantages of the Aniphe BioLablogical Animal Model Platform for Traumatic Brain Injury

The platform boasts mature model‑generation technologies and a comprehensive evaluation system, enabling it to fully meet the diverse needs of scientific research and drug‑efficacy assessment.

Comprehensive model coverage

The model is stable and controllable.

Leveraging established modeling expertise, it can reliably reproduce key pathological features, including abnormal neuronal firing and cerebral hemorrhage with edema.

Standardization of the modeling process

Strictly Selected Inclusion Criteria

Control the variability of baseline parameters among animals within the same batch to ensure the statistical power of the experimental data.

Multidimensional Evaluation System

Multidimensional evaluation system

It supports neurological function scoring, behavioral assessments, brain tissue pathology, and immunohistochemical analyses, enabling a comprehensive evaluation of injury and the efficacy of interventions.

Adapted for multi-cycle studies

Efficient Delivery Services

We provide rapid, reliable model preparation and comprehensive evaluation services to help projects advance efficiently.

Modeling cycle

2 weeks

1  Laboratory animals

A variety of animal species can serve as models for this disease; the most commonly used are mice and rats.

1  Positive drug

These include neuroprotective agents, anti-inflammatory drugs, dehydrating agents, and medications that improve cerebral circulation, which can reduce cerebral edema, suppress inflammation, and protect damaged neurons.

1  Application areas

This model is primarily used for investigating the pathogenesis of traumatic brain injury, screening candidate drugs, validating drug efficacy, and conducting preclinical studies of intervention strategies.

Construction of an Animal Model of Traumatic Brain Injury

Feeney’s free-fall method

A classic Feeney free-fall method was employed to establish a traumatic brain injury model; by applying impact-induced injury using a specialized apparatus, a standardized focal brain injury animal model can be reliably constructed.

Diffuse and Focal Brain Injury in Rats

A rat model of diffuse–focal cerebral injury was established using a heavy‑weight drop method. During the procedure, vital signs—including respiration, heart rate, and blood pressure—were closely monitored, while neurological manifestations such as limb movements and pupillary responses were recorded simultaneously. At various time points after modeling, tissue samples were collected; gross brain lesions were first examined, followed by histopathological analysis through tissue fixation and section staining. Tissue from multiple brain regions could also be obtained…

Specimens were prepared, and microstructural analysis was conducted using electron microscopy.

Model features:

Mechanical traumatic brain injury can be induced by applying a defined external force to the animal’s head; such injuries may be either open or closed.