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Animal model of fracture

Animal model of fracture

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Fracture
Bone-related disease model

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Model Introduction

Model Introduction

Platform Service Advantages

Platform Service Advantages

Model Construction

Model Construction

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Fracture

Introduction to Animal Models of Fractures

Fracture animal models are classic experimental systems for investigating the mechanisms of bone injury repair and regeneration. By mimicking clinical fracture conditions, they enable dynamic observation of the entire fracture-healing process, including inflammatory responses, cartilaginous callus formation, mineralization of the bony callus, and bone remodeling. In studies of established fracture-healing theories, these models are frequently employed to analyze cellular dynamics, callus formation, and the patterns of ultrastructural changes during healing, while also allowing for systematic evaluation of bone‑tissue repair rates, restoration of bone quality, and alterations in mechanical properties. Characterized by well-defined pathological processes, a comprehensive array of assessment parameters, and excellent reproducibility, these models provide a reliable experimental platform for research into fracture-healing mechanisms, the development of osteo‑regenerative therapeutics, and the evaluation of biomaterials and regenerative‑medicine technologies.

Service Advantages of the Aniphe BioLablogical Fracture Animal Model Platform

Leveraging a well-established bone disease model platform and a standardized experimental system, Aniphe BioLab offers high-quality, one-stop research services for fracture animal models.

Comprehensive model coverage

A wide range of modeling options is available.

It supports the establishment of various fracture models, including closed, open, transverse, and defect-type fractures.

Standardization of the modeling process

The model is stable and reliable.

Standardized modeling procedures ensure precise fracture localization, high success rates, and excellent reproducibility.

Multidimensional Evaluation System

Multidimensional pharmacological evaluation

X-ray, micro-CT, histopathology, bone biomechanics, and bone metabolism assays are available.

Adaptable to multi-cycle studies

Supports personalized design

The fracture site, fixation method, and observation period can be customized to meet research requirements.

Adaptable to multi-cycle studies

Standardized Quality Management

Comprehensive quality control throughout the entire process ensures that experimental data are authentic, complete, and traceable.

Adaptable to multi-cycle studies

One-stop experimental services

It covers the entire workflow, from animal husbandry and model development to pharmacological intervention, sample analysis, and data interpretation.

Modeling cycle

6–8 weeks

1  Laboratory animals

Mice and rats with SPF diseases

1  Positive drug

Commonly used anabolic agents include teriparatide, sodium alendronate, bone morphogenetic protein‑2 (BMP‑2), and bone‑healing–promoting formulations, among others.

1  Application areas

It is primarily used for research on fracture‑healing mechanisms, screening of bone‑repair‑promoting drugs and natural bioactive compounds, preclinical evaluation of the efficacy and safety of biologics, cell therapies, bone tissue‑engineering materials, and internal fixation devices, as well as translational studies of technologies related to bone regeneration and repair.

Construction of an animal model of fracture

01 Surgical Method

The target bone (e.g., femur, tibia, or radius) is exposed via surgery, a standardized osteotomy is performed using a bone saw or osteotome, and the fracture is stabilized with an intramedullary nail, a plate, or an external fixator, thereby establishing a stable fracture model. This method offers precise control over the fracture site and excellent reproducibility, making it well suited for studies on fracture healing and bone regeneration.

02 Closed Fracture Reduction Technique (Bedside Fracture Surgery)

Under anesthesia, the animal’s limb is immobilized on a fracture‑induction apparatus, and a closed fracture is induced by applying a standardized external force; intramedullary nailing may be employed when necessary. This method effectively preserves the periosteal and soft‑tissue structures surrounding the fracture, closely mimicking the natural course of fracture formation, and is commonly used to investigate fracture‑healing mechanisms and to evaluate the efficacy of bone‑repair–promoting agents.