Introduction to SP Animal Models

The skin photoaging (SP) mouse model is an experimental system used to study the long-term damage caused by ultraviolet (UV) radiation to the skin. UV radiation is one of the primary external factors contributing to skin aging, and it can lead to dryness, roughness, increased wrinkling, uneven pigmentation, and a heightened risk of skin cancer.

Advantages of Aniphe BioLab’s SP Animal Model Platform Services

Leveraging a standardized UV‑induced modeling system and a specialized evaluation platform, Aniphe BioLab offers end‑to‑end services for the establishment of skin photoaging models and the assessment of their pharmacological efficacy.

	Diverse model categories for versatile compatibility A variety of animal strains are available, supporting UVB/UVA–induced modeling and suitable for a wide range of anti‑aging studies.
	Standardized modeling ensures strong stability. Precise control of UV and environmental parameters ensures phenotypic uniformity and excellent experimental reproducibility.
	A multidimensional and comprehensive evaluation system It comprehensively evaluates drug efficacy by assessing appearance, pathology, oxidative inflammation, and collagen levels.
	One-stop closed-loop experimental services We provide end-to-end services, including animal housing and model establishment, drug administration, testing, and data analysis, to shorten the overall project timeline.
	The experimental protocol is flexible and customizable. Irradiation, drug administration, and sampling conditions can be adjusted as needed to align with regulatory submissions and R&D experiments.

Modeling cycle	4–6 weeks
Laboratory animals	ICR mice
Positive drug	Common retinoic acid, vitamin C and E–based antioxidants, as well as certain topical formulations or active ingredients previously reported to exert anti‑photoaging effects, were employed to assess the model’s sensitivity and reliability in evaluating improvements in cutaneous photoaging.
Application areas	It is primarily used in areas such as screening and evaluating anti‑photoaging agents, developing and validating functional skincare products, investigating the mechanisms of skin aging, and conducting intervention studies on UV‑induced skin damage.

Construction of SP animal models

A skin photoaging animal model was established using a combined UVA/UVB ultraviolet irradiation protocol. Prior to the experiment, the dorsal skin of the animals was shaved to expose and delineate the fixed irradiation area, after which regular UV exposure was administered according to the prescribed dose and time intervals.

UVB primarily acts on the epidermis, inducing DNA damage and localized inflammatory responses; UVA can penetrate into the dermis, promoting the generation of reactive oxygen species (ROS) and accelerating the degradation of collagen fibers. Through repeated, sustained irradiation, this approach progressively elicits hallmark photoaging phenotypes in the skin, including deepening wrinkles, reduced elasticity, epidermal thickening, and disorganized collagen architecture, thereby establishing a stable and reliable animal model of cutaneous photoaging.

Model characteristics: This method is simple to perform, produces distinct phenotypic changes that closely resemble human skin aging, and the skin damage observed in mice is consistent with that seen in photoaged skin. Consequently, this model serves as an effective murine model of cutaneous photoaging.