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Aging animal model

Aging animal model

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Aging
Animal models of other diseases

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Model Introduction

Model Introduction

Platform Service Advantages

Platform Service Advantages

Model Construction

Model Construction

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Aging

Introduction to Animal Models of Aging

As the population ages at an accelerating pace, aging and its associated diseases have become major public health concerns, making the delay of aging and the mitigation of age‑related functional decline key research priorities in life sciences. Aging‑related animal models, by replicating hallmark physiological and pathological changes—such as heightened oxidative stress, chronic inflammation, impaired metabolic function, deterioration of tissue and organ functions, and cognitive decline—provide a robust platform for elucidating the progression of aging and age‑related disorders.

Service Advantages of the Aniphe BioLab Aging Disease Animal Model Platform

Leveraging a well-established aging animal model platform and a standardized experimental system, Aniphe BioLab offers high-quality, one-stop research services for aging-related animal models.

Comprehensive model coverage

The modeling protocols are diverse.

It supports the establishment of multiple aging models, including natural aging, D-galactose‑induced aging, and gene‑related aging.
Standardization of the modeling process

The model is stable and reliable.

Standardized modeling procedures, well-defined aging phenotypes, and high experimental reproducibility.
Multidimensional Evaluation System

Multidimensional evaluation system

Provides assays and analyses for behavioral parameters, histopathology, biochemical markers, oxidative stress, and inflammatory cytokines.
Adaptable to multi-cycle studies

Supports customized research

The modeling cycle, intervention protocol, and evaluation metrics can be adjusted according to research requirements.
Standardization of Data Delivery

Standardized Quality Management

Comprehensive quality control throughout the entire process ensures that experimental data are authentic, complete, and traceable.
Standardization of Data Delivery

One-stop experimental services

It covers the entire workflow, from animal husbandry and model development to pharmacological intervention, sample analysis, and data interpretation.
Modeling cycle

1–4 weeks

1  Laboratory animals

Mice and rats of SPF grade

1  Positive drug

Commonly used positive‑acting compounds include rapamycin, metformin, resveratrol, and nicotinamide mononucleotide (NMN), which can modulate energy metabolism, alleviate oxidative stress, ameliorate inflammatory responses, and slow the decline of physiological functions. These agents are frequently employed in model validation and in the evaluation of anti‑aging pharmacological efficacy.

1  Application areas

It is primarily used for research on aging mechanisms, screening anti‑aging drugs and natural bioactive compounds, as well as for preclinical in vivo efficacy evaluation and mechanistic studies of health foods, biologics, functional products, and regenerative medicine–related products.

Construction of an Animal Model of Aging

Pharmacokinetics Experiment; Phase I Study

Two groups were established: 2-month-old young mice and 10-month-old aged mice, with six animals in each group. Plasma and liver samples were collected at four time points—0, 10, 30, and 60 minutes after administration—requiring a total of 60 mice to compare drug metabolism differences between young and aged individuals.

Pharmacokinetics Experiment; Phase II Study

Mice receiving drug A continuously from 16 months of age were assigned to the experimental group, and their metabolic profiles were compared with those of a 10-month-old aging control group. In the long-term administration study, three additional groups were concurrently established: a 10-month-old aging blank control group, a 10-month-old group receiving drug A, and a 10-month-old group receiving drug B as a positive control, to investigate the effects of chronic drug administration on the metabolism of aged mice.

Model characteristics: Premature aging models can significantly shorten the research timeline. Natural aging animal models more closely mimic the human aging process.

 

Test data

Body weight, body fat percentage, oxygen consumption, energy expenditure, respiratory quotient measurement, morphological and visual assessments, electroretinography, serum levels of glucose, total cholesterol, triglycerides, and free fatty acids (FFA), fecal pH, aging index scoring, hepatic H&E staining, hair follicle stem cell sectioning, assays for SASP‑related factors and for markers of inflammation, oxidative stress, and antioxidant status, Western blot analysis of protein expression levels of three mitochondrial respiratory chain complexes in liver mitochondria, qRT‑PCR analysis of senescence‑associated genes, 16S rRNA profiling of the gut microbiota, bile acid metabolism, short-chain fatty acids (SCFAs), and hepatic microRNAs.