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Periodontitis PD animal model

Periodontitis PD animal model

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Chronic periodontitis
Psychiatric & neurological disease models

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Model Introduction

Model Introduction

Platform Service Advantages

Platform Service Advantages

Model Construction

Model Construction

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Chronic periodontitis

Introduction to PD Animal Models

Periodontitis (PD) is a chronic infectious inflammatory disease induced by plaque‑associated microorganisms, which can lead to gingival inflammation, destruction of the periodontal tissues, alveolar bone resorption, and tooth mobility and loss, making it one of the leading causes of tooth loss in adults. Rat models of periodontitis, by mimicking sustained inflammation and bone resorption in the periodontal tissues, effectively recapitulate hallmark pathological features such as gingival inflammation, loss of periodontal attachment, and alveolar bone destruction, enabling dynamic assessment of inflammatory responses, alterations in bone metabolism, and tissue repair processes.

Advantages of Aniphe BioLab’s PD Animal Model Platform Services

Leveraging a well-established oral disease model platform and a standardized experimental system, Aniphe BioLab offers high-quality, one-stop animal model research services for periodontitis (PD).

Comprehensive model coverage

The modeling protocol is well-established.

Supports multiple periodontitis modeling approaches, including cervical ligature and apical periodontitis models.
Standardization of the modeling process

The model is stable and reliable.

A standardized modeling protocol ensures high phenotypic consistency in periodontal inflammation and alveolar bone resorption.
Multidimensional Evaluation System

Multidimensional evaluation system

We offer micro-CT, histopathology, alveolar bone quantitative analysis, and assays for inflammatory cytokines and immunological markers.
Adapted for multi-cycle studies

Supports customized research

The modeling cycle, administration route, and observation endpoints can be tailored to meet the specific research requirements.
Adapted for multi-cycle studies

Standardized Quality Management

Full-process quality control ensures that experimental data are authentic, complete, and traceable.
Adapted for multi-cycle studies

One-stop experimental services

It covers the entire workflow, from animal husbandry and model development to pharmacological intervention, sample analysis, and data interpretation.
Modeling cycle

4–20 weeks

1  Laboratory animals

Mice, rats, and pigs

1  Positive drug

Commonly used antibacterial agents include minocycline, doxycycline, metronidazole, and amoxicillin, which can inhibit the growth of periodontal pathogens, reduce inflammatory responses, slow alveolar bone resorption, and promote periodontal tissue repair; they are frequently employed in model validation and pharmacological efficacy assessment.

1  Application areas

It is primarily used for studying the pathogenesis of periodontitis, screening antibacterial and anti-inflammatory agents as well as drugs for periodontal tissue repair, and conducting preclinical in vivo efficacy evaluations and mechanistic studies on oral biomaterials, regenerative medicine products, tissue-engineered constructs, and locally administered formulations.

Construction of a PD animal model

01 Cervical Ligation Method

In rats, a ligature is placed around the cervical region of the molar teeth to promote the accumulation of dental plaque and food debris, thereby inducing a localized inflammatory response and periodontal tissue destruction. Over time, this leads to the development of typical periodontitis–related lesions, including gingival inflammation, loss of periodontal attachment, and alveolar bone resorption. This method is simple to perform, yields stable and reproducible models, and is one of the most widely used approaches in periodontitis research.

02 Apical Periodontitis Model

By exposing the pulp or preparing a root canal to induce infection, bacterial colonization and persistent inflammation are triggered in the periapical region, leading to periapical tissue inflammation and alveolar bone resorption. This model effectively mimics the pathological processes of clinical chronic apical periodontitis and is well suited for studies on the pathogenesis of periodontitis, anti-infective therapies, and tissue repair mechanisms.