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Tool mouse

● Conditional Modifier Key: Tool mice are the “key” to modern conditional genetic modification research, and Aniphe Biolaboratory offers a wide range of tool mouse strains, including Cre and Cre‑ERT2 reporter mice driven by tissue-specific promoters.

● Visualized Tracing System: We provide a variety of fluorescent and luminescent reporter‑gene mouse models (e.g., EGFP, TdTomato, Luciferase) to facilitate in vivo spatiotemporal tracking.

● Precise and timely air conditioning control: Following crossbreeding with Flox mice, the target gene can be precisely activated or silenced at specific developmental stages or in particular tissues and organs, making this approach an indispensable tool for lineage tracing, directed cell differentiation, and the study of complex biological mechanisms.

Background strain Mouse name Expression position Gene-editing methods Application Instructions
C57BL/6 Alb-cre Liver Tg cre expressed in hepatocytes; very efficient in achieving liver-specific recombination when crossed with liver specific floxed alleles.
C57BL/6 CAG-CreERT Embryo, widely expressed Tg tamoxifen-inducible cre; widespread pattern of expression; tamoxifen administration will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice
C57BL/6 CaMK2-Cre Brain tissue Tg This transgene directs the expression of Cre recombinase under the control of the alpha subunit of the calcium/calmodulin-dependent protein kinase II promoter. Cre recombinase activity was detected in the CA1 region of the hippocampus.
C57BL/6 Carp-cre Brain tissue Tg Brain-specific Cre transgenic mice
C57BL/6 Cd19-cre B cells Tg In frame insertion of a cre recombinase gene into the first coding exon followed by an frt-flanked neomycin cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development.
C57BL/6 CMV-CRE Widespread expression Tg This transgene expresses Cre recombinase under the control of a human cytomegalovirus (CMV) promoter, active in most cells and tissues.
C57BL/6 Col1-cre Osteoblast Tg Inducible cre recombinase activity is detected in the osteoblasts of the long bones of the limbs and in the ribs, vertebrae and calvaria in 18.5 embryonic day aged and 18 day old mice.
C57BL/6 Col2-gfp Chondrocyte Tg An EGFP fluorescent reporter is expressed from the murine Col2a1 promoter, providing an in vivo/in vitro tool for the studies of chondrocyte differentiation and cartilage matrix synthesis.
C57BL/6 Col2-cre Chondrocyte Tg cre expression is directed to cells of the chondrogenic lineage (cartilage) during embryogenesis and postnatally
C57BL/6 Fabp4-cre White and brown adipose tissue Tg The FABP4-Cre transgene has a mouse Fabp4 promoter directing expression of Cre recombinase. These FABP4-Cre transgenic mice are a Cre-lox tool useful for deletion of floxed sequences in brown and white adipose tissue.
C57BL/6 GFAP-Cre Astrocytes in the brain and spinal cord Tg  
C57BL/6 GFPA-Cre   Tg  
C57BL/6 Gpr126-Cre   Tg  
C57BL/6 Gαq Lysom-Cre   Tg  
C57BL/6 Ipf1-cre These mutant mice carry loxP sites flanking exon 2A of the Pdx1 gene. Tg These floxed mutant mice possess loxP sites flanking exon 2A of the Pdx1 gene. This strain may be useful for generating conditional mutations in applications related to the pancreatic development, pancreatic beta cell function, tumorigenesis, tumor progression and metastasis.
C57BL/6 Lck-cre T lymphocyte expression Tg This transgenic strain expresses Cre under the control of the Lck (lymphocyte protein tyrosine kinase) promoter, enabling thymocyte-specific excision of loxP-flanked sequences of interest. The Lck gene is primarily expressed by T lymphocytes and it plays a key role in the selection and maturation of developing T-cells in the thymus and in the activity of mature T-cells.
C57BL/6 Lgr5-CreERT2   Tg  
C57BL/6 Lgr5-EGFP-Ires-Cre(ERT2) Expresses an EGFP–CreERT2 fusion protein. Tg Heterozygous mice harbor an Lgr5-EGFP-IRES-creERT2 "knock-in" allele that both abolishes Lgr5 gene function and expresses EGFP and CreERT2 fusion protein. When these mice mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Lgr5-expressing cells of the offspring. These mice may be useful for lineage-tracing or marking Lgr5-expressing stem cells of the small intestine.
B6.129P2 Lyz2-Cre Re-mediated excision of the targeted region results in knockout alleles. Tg Exon 4 of the mouse Itgav gene is flanked by loxP sites in these αvflox mice. Cre-mediated excision of the floxed region results in a knock-out allele useful in studies of ulcerative colitis, autoimmunity, vascular development, and cancer.
C57BL/6 Lyz2-Cre   Tg  
C57BL/6 MHC-Cre Cardiac-specific α‑myosin heavy chain (Myh6) promoter–driven Cre Tg The cardiac-specific alpha myosin-heavy chain (Myh6) promoter drives expression of cre in this transgenic strain. The promoter induces greater than 90% recombination in cardiac muscle cells.
FVB MMTV-Cre Transgenic organism containing Cre recombinase Tg These MMTV-Cre/Line D mice express a transgene containing Cre recombinase with widespread expression (but not in oocytes) under control the MMTV LTR promoter.
C57BL/6 Mx1-cre It is possible to perform “knockout” at any stage of development in the progeny of this transgenic flax mutant. Tg The Cre recombinase is under the control of the Mx1 promoter, which can be induced to high levels of transcription by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA (such as poly I:C); enabling the "knockout" at any time during development in progeny of a floxed mutant mated to this transgenic.
B6.FVB Myh11-cre/ERT2 Conditional gene deletion in smooth muscle cells Tg These mice may be useful for the conditional deletion of genes in smooth muscle cells.
C57BL/6 Nestin-Cre Cre recombinase driven by the nestin promoter in the central and peripheral nervous systems Tg This strain is commonly known as nestin-Cre. Nestin promotor driven Cre recombinase is expressed in the central and peripheral nervous system, including neuronal and glial cell precursors. There are reports of Cre recombinase activity in a few isolated kidney and heart cells. Hemizygous nestin-cre mice exhibit mild hypopituitarism, growth retardation, impaired fear response, and a metabolic phenotype. Mice also show a strong impairment in the acquisition of both contextual- and cued-fear conditioning.
C57BL/6 Nestin-creERT Tamoxifen-induced Cre recombinase Tg Nestin-Cre/ERT2 transgenic mice express tamoxifen-inducible Cre recombinase in adult and developing mouse brain, including neuronal and glial cell precursors.
C57BL/6 Nestin-gfp Enhanced green fluorescent protein targeting embryonic brain neuroepithelium Tg Nestin-GFP mice express an enhanced green fluorescent protein (EGFP) directed to the neuroepithelium of the embryonic brain using the regulatory elements of the Nes (nestin) gene. This mutant mouse strain may be useful in visualizing neural stem and progenitor cells in embryonic and adult brains.
C57BL/6 Optogenetic-Cre   Tg  
C57BL/6 Osx-Cre Maintenance of hematopoietic stem cells Tg Exon 2 of the mouse Cxcl12 (chemokine (C-X-C motif) ligand 12) gene is flanked by loxP sites in this conditional targeted mutation strain. Cre recombinase-mediated excision of the floxed region enables tissue/cell-specific knockouts of the gene, useful in studies of hematopoietic stem cell maintenance or other CXCL12-dependent processes.
C57BL/6 Pdx1-Cre Pancreas-specific conditional mutation Tg These Pdx-Cre transgenic mice express Cre recombinase under the control of the mouse Pdx1 promoter and may be useful for generating pancreas-specific conditional mutations.
C57BL/6 Pdx1-cre/Esr1 Conditional pancreatic cell knockout Tg This tamoxifen-inducible Pdx1-Cre/Esr1 strain may be used to create conditional pancreatic cell knockouts when crossed with strains carrying floxed alleles.
C57BL/6 PP2ac-Cre   Tg  
FVB Rank-Cre Metabolic disorders and the regulation of bile acid, lipid, and glucose metabolism Tg Fxrfl (loxP::exon::loxP::Δneo) is a floxed allele - loxP sites flank the last exon of the Nr1h4 gene. Removal of the floxed sequence creates a null allele. These mice may be useful in studying metabolic disorders, as well as the regulation of bile acid, lipid and glucose metabolism. Δneo)
C57BL/6 Rosa26-lacZ   AI  
C57BL/6 Rosa26-Lsl-EGFP Green fluorescence AI  
C57BL/6 Rosa26-tdTomato Red fluorescence AI  
C57BL/6 RUNX2-CRE Osteogenesis research AI These Runx2-BioFL knock-in mice express a RUNX2 protein with a C terminus biotin/FLAG tag. They are suitable for use in ChIP-seq applications and in studies of osteogenesis.
C57BL/6 SPC-Cre Brain and bone tumors, lymphoma Tg Trp53 knockout mutant mice develop tumors at three to six months of age. They are suitable for use in applications related to the study of familial breast cancers such as Li-Fraumeni syndrome as well as research of lung, brain and bone tumors, lymphoma and leukemia, and other rare cancers.
C57BL/6 UCP1-egfp This mutant mouse strain is useful in studies of obesity, metabolic homeostasis, and adaptive thermogenesis. AI These Ucp knock-out mice are sensitive to cold temperatures, exhibit altered metabolism and are resistant to diet induced obesity when maintained at 20°C. This mutant mouse strain may be useful in studies of obesity, metabolic homeostasis, and adaptive thermogenesis.
C57BL/6 Vav-cre Conditional mutation in hematopoietic cells Tg Vav-iCre transgenic mice have the mouse HS21/45 control regions directing expression of an optimized variant of Cre recombinase (iCre) to hematopoietic cells (and their progenitors), and may be useful for generating conditional mutations in hematopoietic cells.
C57BL/6 Villin-Cre Cre recombinase is expressed in the epithelial cells of the villi and crypts of both the small and large intestines. Tg These Vil1-cre mice express Cre recombinase in villus and crypt epithelial cells of the small and large intestines and may be useful in studies of intestinal organogenesis. In contrast to Villin-cre transgenic mice from founder line 1000 (Stock No. 021504) that are reported be absent of Cre recombinase activity in gonads, these Villin-cre transgenic mice from founder line 997 are reported to have a very low level (<1%) of cells with Cre recombinase activity in the testes.
C57BL/6 Villin-CreERT2 Intestinal crypt villus axis Tg vil-Cre-ERT2 mice carry a transgene with tamoxifen inducible Cre recombinase under the control of the 9 kb mouse Vil1, villin 1, promoter, and may be useful for generating specific targeted mutants for studies of the crypt-villus axis of the intestinal epithelium.
C57BL/6 α-MHC-Cre Cardiomyocyte Tg The cardiac-specific alpha myosin-heavy chain (Myh6) promoter drives expression of cre in this transgenic strain. The promoter induces greater than 90% recombination in cardiac muscle cells.