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Bleomycin-induced pulmonary fibrosis model in mice

　　Pulmonary fibrosis is a group of diseases characterized by irreversible lung damage resulting from abnormal tissue repair, with high mortality, extremely poor prognosis, and an unclear pathogenesis; currently, there are no specific therapeutic agents available. Based on a mouse model of pulmonary fibrosis induced by bleomycin (BLM), we aim to further identify biomarkers for pulmonary fibrosis, thereby providing a scientific foundation for in-depth investigation into its pathogenic mechanisms, preclinical evaluation of potential therapies, and the development of novel drugs.

　　Modeling method

　　Species and strain of the animal: BALB/c mice

　　Animal sex: Female

　　Animal age: 6 weeks old

　　Animal weight: 20–25 g

　　Preparation environment: Barrier environment

　　Preparation period: 4 weeks

　　Preparation method: A pulmonary fibrosis model was established by intratracheal administration of bleomycin (BLM).

　　Evaluation criteria

　　(1) Sampling and Observation

　　(2) Histopathological Examination

　　Results Display

　　●Histopathological Examination●

　　Comparison between the normal group and the model group: In the lung tissue of model mice, interstitial capillaries exhibited congestion and dilation, alveolar walls became thickened and even ruptured, and the alveolar spaces showed inflammatory cell infiltration dominated by neutrophils.

The Impact of Biological Hazards on Laboratory Animals

Is there a “one-size-fits-all” approach to selecting primary and secondary antibodies for immunohistochemistry?