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Psychiatric & neurological disease models
Aniphe BioLab has established an integrated laboratory animal resource platform covering genetic resource preservation, IVF-assisted breeding, SPF rederivation, and managed breeding services, providing full-cycle solutions from long-term genetic preservation to efficient colony expansion.Through sperm and embryo cryopreservation, IVF-ET, and SPF rederivation technologies, we enable secure genetic resource storage, rapid colony expansion, and recovery of contaminated strains. Combined with standardized breeding and husbandry management, our platform ensures process traceability, improves batch consistency and animal supply reliability, and reduces facility operating costs.We provide high-quality, sustainable laboratory animal resources to support academic research and biopharmaceutical development.
Precision Modeling
System Verification
Repeatability
Accelerate R&D
Related Resources
Characteristics of Aniphe BioLab Models for Mental and Neurological Disorders
In response to the complexity of central nervous system disease research and the need for multidimensional evaluation, Ailinfei Biotechnology has established a standardized animal model platform that encompasses behavioral assays, molecular mechanisms, and pathology, ensuring model stability and data consistency.
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It encompasses mainstream neuropsychiatric disease models, including depression, anxiety, schizophrenia, and cognitive disorders, thereby meeting the needs of different stages of research. |
Standardize stress‑induction protocols and experimental timelines to minimize confounding effects from behavioral and environmental factors. |
By integrating behavioral outcomes, neurotransmitter alterations, and brain tissue pathology, we achieve a simultaneous assessment of function and underlying mechanisms. |
Provide raw behavioral data, imaging records, and analysis results to ensure the traceability of experimental outcomes. |
Such models, by integrating behavioral phenotyping with central nervous system mechanisms, provide a stable and reproducible in vivo experimental platform for drug screening and mechanistic studies of psychiatric and neurological disorders.
Product List:
Disease Name
Disease model
Details
The various in vitro drug‑screening models established can provide an effective evaluation of drug efficacy and serve as a robust approach for early‑stage drug discovery.
Based on the drug’s mechanism of action, an appropriate animal disease model reflecting the relevant pathogenic pathway is selected, accompanied by a comprehensive suite of diagnostic tools, including pathological, histological, and behavioral assessments.
The objective of preclinical drug toxicology studies is to characterize and identify the toxic effects of a drug, determine its target organs and the relevant dose range, assess whether these toxic effects are reversible, elucidate the underlying mechanisms of toxicity, and conduct a comprehensive and systematic evaluation of the drug’s safety profile, thereby providing critical reference data for clinical trials.
Preclinical pharmacokinetics applies principles of kinetics and mathematical modeling to quantitatively characterize the time-dependent dynamics of a drug’s absorption, distribution, metabolism, and excretion.
Used to assess the product’s suitability prior to finalization, and to conduct preliminary verification of its safety and efficacy.
We offer testing services for stem cell product toxicity, immune adverse reactions, tumorigenicity, and unintended differentiation, as well as in vivo assessments of stem cell survival, distribution, homing, differentiation, tissue integration, disease‑modifying effects, and immunomodulatory activities.
Animal model of electrical stimulation for traumatic brain injury
Animal model of minimal hepatic encephalopathy (MHE)
Myocardial ischemia MI/myocardial ischemia-reperfusion animal model
Metabolic Dysfunction-Associated Steatohepatitis (MASH) Animal Model
Animal model of biliary obstruction recanalization
Animal model of hepatic ischemia-reperfusion injury (IRI)
Alcoholic liver disease (ALD) animal model
Chronic Obstructive Pulmonary Disease (COPD) Animal Model
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Disease Name |
Disease model |
Construction method |
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Migraine |
Migraine model |
Nitroglycerin injection, dural inflammation-induced stimulation (application of inflammatory substances) |
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Hypopituitarism |
Pituitaryectomy model |
Surgical removal of the pituitary gland (via the transsphenoidal or transcranial approach) |
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Suppurative osteomyelitis |
Experimental model of osteomyelitis |
Tibial drilling and injection of Staphylococcus aureus |
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Ischemic tolerance induction |
Hypoxic preconditioning model |
Severe ischemia induced after repeated short-term hypoxic exposures (in normobaric or hypobaric chambers) |
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Vestibular dysfunction |
Unilateral labyrinthectomy model |
Surgical destruction of the unilateral vestibular apparatus in rats and guinea pigs. |
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Antipsychotic-induced bone loss |
Schizophrenia-induced osteoporosis model |
Long-term administration of antipsychotic agents (such as haloperidol) in combination with ovariectomy or glucocorticoid induction |
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Periprosthetic osteolysis |
Cranial bone dissolution model |
Cranial implantation of titanium particles or inflammatory factors (TNF-α/polyethylene particles) |
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Post-ischemic epilepsy |
Global cerebral ischemic epilepsy model |
Seizures following bilateral common carotid artery ligation and hypotension-induced ischemia |
Aniphe BioLab Inc.
Address:
Runcheng, No. 8 Longtai Road, Jiangbei New Area, Nanjing City, Jiangsu Province
Building 8, Science Park
Postal Code: 210007
Phone:025-8520 8061
Email:info@aniphebio.com(Consultation)
Email:order@aniphebio.com(Order)
WeChat Official Account
Video Account
Su Public Security Bureau Internet Information Service Filing No. 32010402001421